Regulation of transcription and translation by stress-derived fragments of stable structural RNAs (sfrRNAs)

Stress-induced rRNA decay is accompanied by a massive accumulation of stable stressderived fragments (sfrRNAs) that are generated from both mature and precursor rRNAs, mainly in the

cytoplasm, but also in the nucleus. Our bioinformatics analyses predict and classify potential sfrRNA sense and antisense mRNA targets based on a high sequence overlap with mapped rRNA fragments. We investigate the contribution of sfrRNAs to the regulation of gene expression during stress on the level of transcription and translation.